His main bass is a mid-80's Fender Jazz Bass Special, however McKagan has also become a fan of the new Fender Aerodyne bass. He uses Seymour Duncan Pickups. He never uses active basses. His first amp was a Gallien-Krueger GK400RB. His current heads are Gallien-Krueger 2001RB with Gallien-Krueger 4x10 speaker cabinets. He uses Dunlop picks, straps and straplocks.
In October 2007, Fender released a Duff McKagan signature P Bass model, based on his main Jazz Bass Special.